Zoe and Wash are too perfect for anything else to work, really. They're one of the very few ships where I say "OTP" and really MEAN it that way. Because fdjalfjdafkjdsfjdsfkljdsjafds :p

River/Jayne is probably the most popular non-canon ship. ANd it SQUICKS THE HELL OUT OF ME. River is just too messed up to be getting into ANY relationship. She's not capable of CONSENTING to such things.